The summer is not only a station

28 07 2011

In DOCTOPOLIS We believe that the summer is not only a station, but much more!! Is explained through a video that's worth see.

Take this opportunity to let you know that we enjoy the summer working, so holiday we will be at your disposal for anything you need.

We wish you good holidays!! and, above all, good feelings!!

The DOCTOPOLIS team

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They get that tumor cells of the liver recover the ability to self-destruct

25 07 2011

Studying markers that can predict the response of liver tumor cells to epidermal growth factor receptor inhibitors (EGFR)

The discovery could allow advance towards treatments custom in this type of tumors

Inhibition of epidermal growth factor receptor (EGFR) It slows the growth of liver tumor cells and makes them sensitive to the suppressing action of the cytokine TGF-beta, by activating mechanisms of programmed death (apoptosis). This is the result of an investigation conducted by researchers in the biological key of the invasive Phenotype and metastatic group of the IDIBELL, led by Isabel Fabregat.



The results of the study could lead to the development of new therapies against liver cancer custom. The work is published in the August issue of the Magazine Journal of Hepatology.

Hepatocellular carcinoma is one of the tumors with more mortality in the world and the fifth most common. The appearance of this tumor is related to several molecular alterations, the most obvious being the alteration of the mechanisms that regulate the balance between proliferation and cell death.

Dual role of TGF-beta

The objective of the study is to dissect the response of tumour cells to TGF-beta when aborts the EGFR via. TGF-beta is involved in the regulation of several cellular processes. With regard to tumors, has demonstrated that it has a contradictory dual role. On the one hand, in initial States induces programmed cell death, so you have a suppressing tumor growth function, but in more advanced States favours cell invasion and migration and, It is therefore, metastasis.

The cancellation of the EGFR pathway was pharmacologically and silencing their expression through the use of RNA interference with the same results. Inhibition of the EGF receptor not only attenuates cell proliferation, but it also increases the suppressing function of TGF-beta, Therefore it might be a therapeutic target for liver cancer. Now well, This brake on the growth of tumor cells does not occur in all cases. The cell lines that have certain genetic disorders (in the operation of the TGF-beta or the proteins involved in the EGFR signaling pathway, but subsequent to the receiver steps) do not respond to EGFR inhibition and tumor cells continue to grow.

The Coordinator of the study, Isabel Fabregat, emphasised that you to make "a good personalized medicine is necessary to analyze the molecular biology of tumor cells of the patient", their phenotype and your background of genetic and epigenetic; "so you can predict which patients are likely to respond effectively to the treatment and what not".

The study has been done in hepatocellular carcinoma cell lines and in the coming months will begin a study with an experimental model in mice.

The article reference

Box L., Sancho P., BERTRAN (E)., Fabregat I. Dissecting the effect of targeting the epidermal growth factor receptor on TGF-B-induced-apoptosis in human hepatocellular carcinoma cells, Journal of Hepatology (2010), DOI: 10.1016/j.jhep.2010.10.041

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NETWORKS: Instead of diseases, health care

21 07 2011

The lack of plasticity of salu systemsd will soon face the challenge of technologies inWired and genomics.
Eric Topol

Eduard Punset:
On one occasion I heard something that made my imagination. Once said something like that, in the future, medicine will not deal with disease, health and welfare. And you add must be to the great revolution that is coming, Thanks to wireless medicine and genomics. Do we explain you to our audience really approaching something extraordinary??

Eric Topol:
Of course, Let's see. We now think it would be fabulous to be able to prevent diseases before they appear. Unfortunately, medicine has focused primarily on the control of diseases and has not been able to prevent them. Is mainly due to the fact that lacked technology to do so. But it is changing, It is very quickly changing our ability to understand each individual at the biological level, anatomical, physiological, whichever is, a complete discovery of each person.

Eduard Punset:
You also speak of genomics, of knowledge derived from genomics and, under this agenda item, I think, I feel that the man in the foot is deranged, You know, When you compare what people see with what Clinton said, for example, on the radical changes, revolutionaries even, Genomics could be in everyone's life; There is a sense that things have not gone as we thought.

Eric Topol:
Well, I think that to some extent it is true. More or less a decade has passed since the first human genome was sequenced.

Eduard Punset:
It is true.

Eric Topol:
And at the bottom it is not long. During that time envisaged, We are talking about when Clinton was in the White House, in June of 2000, with Collins and Venter, was anticipated that we would have a total renovation of the medicine. We have not yet seen, but there are the first signs in genomics. For example, many of the medications we use regularly, the medical prescriptions, medication, We can adapt them to the patient and so make sure that it will work, We cannot guarantee that they will not have serious side effects, We can make sure that they are given the appropriate dose of the appropriate drug and avoid wasting so these medicines as well as serious side effects. The other big change that find me exciting is that, in December of 2010, was the first case of a child suffering from a rare disease, that I have never seen before here, in Milwaukee, Wisconsin, in the United States. For years, He developed a fistula from the intestine to the skin. He was suffering from terrible infections. They had to operate over a hundred times and it was going to die. They had their genome sequenced.

Eduard Punset:
Its genome...

Eric Topol:
Yes, which revealed the cause, the root cause of your illness. He underwent a specific treatment for the disease, If a bone marrow transplant. It is now a healthy six-year-old boy, He leads a normal life and it saved my life thanks to the genetic sequencing. So we needed all these years but the current progress are huge. It has been possible thanks to the sequencing of the genome and not just some parts as we had done so far. And it's a big step in the right direction. Still we can not cure, for example, the cancer but now know some of the causative genes. It is to analyze the root cause. This is what the genome allows us to analyse, What is the root cause of the cancer that affects a person, which is fabulous.

Eduard Punset:
It's amazing because I'm thinking, the work, your research center is called Scripps Translational Science Institute and I remember having spoken many times with a friend my oncologist, and have you said: “Mira, that period of time between that you discover something about genomics and you can apply it is too long, really...”. They did take ten years or even...

Eric Topol:
Seventeen, Media.

Eduard Punset:
Seventeen years??

Eric Topol:
It's horrible.

Eduard Punset:
It's horrible. The word? “transferring” It has something to do with the desire to reduce..., to work together, say, the scientist, the patient, the doctor in order to reduce the time?

Eric Topol:
You hit the nail on the head. “Transferring” It means to turn basic science into something which mark the difference in terms of health and makes it quickly, as fast as possible. And that's what it means “transferring”. It used to be called “the Valley of death”, that is to say, These two containers which are the basic science and the world of medicine did not speak, so the big ideas that arose from one side just died. It's combining ideas, build bridges, but it must be done quickly to catalyze and accelerate the findings, to change the future of health and medicine.

Eduard Punset:
Listen to me, I'd love my audience know something about wireless devices... Let's talk about some of these devices.

Eric Topol:
Course, of course. I'll show a couple of things… Well, It all began in the world of fitness. Put a sensor in a sports shoe and so people could use this sensor to transfer data to their phones and know the distance that had covered, at what speed, This kind of thing. The next step were the accelerometers, It allowed to know few steps gave the day. A wireless accelerometer, much better than the pedometer, very accurate, up to ten thousand steps. After this, a device found, very interesting, It allowed to measure brain waves. All the time, At home, While we try to sleep, While we sleep. It is a very interesting technology because...

Eduard Punset:
Do you want to know your brain waves??

Eric Topol:
Well, because it can help you sleep better. Or if you have a sleep disorder. For example, These are my brain waves in every minute of sleep. I know at what stage of sleep I am carrying a tape head at night. It is a very interesting device for quantifying the dream. Wireless objects are changing... You know, the person is like a black box. Do you know when an aircraft has an accident and is looking for the black box??

Eduard Punset:
Yes, that's.

Eric Topol:
In fact, the black box is orange but, well, gives equal. Show me, you are looking for to be able to register any event, now everything is logged. If you would like to attend to a patient who is hospitalized, I look at my phone and see how it evolves in this very moment, at this very moment, a specific patient that is entered. So I'm looking for and check it in my phone and see how is now: the electrocardiogram, blood pressure, the temperature, the oxygen in blood at this moment. And soon we will be able apply us it to ourselves because it's the same technology as the mobile, We know all our vital constants.
And instead of having the black box for someone that has crashed, We have the black box for someone who is alive and well...

Eduard Punset:
Until you crash.

Eric Topol:
Until you crash. It is the key, is the key. And we have this other device here. It's a heart ultrasound, VES, You can.... The heart is collapsed.

Eduard Punset:
Is this the heart??

Eric Topol:
Yes. And I put this ultrasound probe - is the same size as any mobile- I can place it where you want to, in the arteries, in the neck, in the heart, in the abdomen...

Eduard Punset:
Can you put it in my heart and...??

Eric Topol:
You could do. You could...

Eduard Punset:
Do it!! Because I have an arrhythmia...

Eric Topol:
Do you have an arrhythmia??

Eduard Punset:
I have paroxysmal atrial fibrillation.

Eric Topol:
Would I like you to do a scan??

Eduard Punset:
Yes, would be wonderful.

Eric Topol:
You have atrial fibrillation all the time or only to times??

Eduard Punset:
No, not, all the time now. It is permanent. Cuando eres joven, you know very well as a cardiologist, cuWhen you are younghave paroxysmal fibrillation crisis, but as you get older or adult, say, becomes something permanent. And notes it all the time. But it is much more mild and not already hurts.

Eric Topol:
De acuerdo, We are going to make you the cardiac examination, then. We need cold gel. I'll have to ask you to desabroches you with the shirt...Ah, is already,I agreeo. Agreement here is, There is your heart. This image is really good. Beautiful girl. It shows the very strong heart muscle. The valves are precious. The left atrium is great, Hence the fibrillation, but your heart rate is very controlled. Your muscles are very strong, see?? The contraction is very good and the mitral valve is normal. But you have a very large left atrial. Do you suffer from high blood pressure??

Eduard Punset:
Sometimes.

Eric Topol:
Because your muscles are very thick, so you probably have high blood pressure. Not have check you it well all these years?, nervous tension? It has been low, or it has been rather uncontrolled??

Eduard Punset:
Well, I've had high.

Eric Topol:
Yes, is what I see.

Eduard Punset:
And took some pills to take very short.

Eric Topol:
Yes. VES, probably your Genetics is conducive to hypertension and possibly to atrial fibrillation, but you have a very strong heart. The contraction is fantastic.
Not only I could do you a heart scan. I don't have to listen to you heart because I see, see it all. But, Why is it important in the world of the wireless era?? Because I can send this... Let's say that if it wasn't cardiologist... I can send this to the expert via wireless and I can answer immediately, in the room of emergency or on the ground. This is what the wireless medicine, is a completely new technological world.

Eduard Punset:
A program like this is already something, But what else can we do really to accelerate these changes towards this new medicine based on wireless technology?

Eric Topol:
Well, We have much to do because the current medicine is practiced at a different level, It is taking as a reference the general population. All women should have a mammogram. Everyone has to do a colonoscopy. Men have to do an analysis for the prostate. That is not the medicine which we want to exercise. We want an individualized medical practice. It's a change that has not been. We have to change this, This whole process: When these tests are ordered with so many people, trials with hundreds, hundreds of thousands of patients for many years... It is something that has prevented many people progress. We need to change this philosophy and it is possible to change. It is only a different approach because there are new capabilities to do so. Let's go back to your case. You have hypertension, but you had no way of measuring your high blood pressure all the time with the phone. Now you can do, so you know how is your blood pressure because it will beep, beep and, then, you know that you have high blood pressure and you can control it better. This will cause the heart muscles walls thin and you will have less chance of ever an abnormality of heart rhythm. So we are talking about preventing disease in persons through sensors, to know your genomics... It is a life change but we will need time until it is accepted universally.

Eduard Punset:
AND, In addition, of course, all the news that you are discovering they are. I have read that you to avoid cholesterol, There is a medicine called a concrete “Statin” that uses people. What the Statin??

Eric Topol:
Well, Statins, This is how we call them, they are drugs with names as Lipitor, CRESTOR, Zocor... Well, gives equal, are those drugs which are more prescribed worldwide. Take them tens of millions of people to reduce your blood cholesterol. However, If there is no heart disease, the proportion of people who can benefit from them and avoid a heart attack is very small, or a stroke, or death. If treat 100 people who do not have heart disease with Statins, all will get better results in laboratory tests, but only a, two or three will have less propensity to suffer a heart attack. So we are medication one hundred people throughout his life, When only one or two leave benefit, and we should not forget that it is drugs that are expensive. So, with luck, We can do things better. It is not that statins are bad but it recetár them to who need them. We still don't know how to do it, but things are going to change.

Eduard Punset:
There is a..., I think..., I don't remember the exact figure, Perhaps Fourteen million or 20 million Americans who suffer from diabetes. I do not remember exactly how many millions are...

Eric Topol:
Well, in the United States, thirty million. And 300 million worldwide. And this which have only been diagnosed. It is an epidemic.

Eduard Punset:
It is an epidemic, the truth.

Eric Topol:
Sí, Yes.

Eduard Punset:
Something new in this field?? Any novelty in wireless medicine and genomics as possible...??

Eric Topol:
Sí, Yes. Wireless medicine and genomics are fantastic in the cases of diabetes. First of all, If you are a diabetic, You can make a genomic classification that say why have you developed diabetes. Why?? There are many reasons that can lead to the development of diabetes. Discover what fault the person: If the pancreas that has failed or the transport of insulin has been… Además, We can insert them a subcutaneous sensor, a small needle under the skin, record levels of glucose and send the results to a terminal such as a mobile phone constantly, so you can see blood glucose levels every five minutes. Is important this?? Well because to control diabetes, you have to know glucose levels 24 hours a day. We can not know simply by clicking a fingertip. And so you know while you sleep or if you're disgusted, in any circumstances of the day, you know if the glucose you tripped, If something you've eaten and which has today you gone bad, Why have a rise or fall of glucose. It is really important to control diabetes each patient individually. Además, is trying to avoid that it reappears diabetes. All we can do is the most important thing.In addition

Eduard Punset:
You know, My father was a country doctor and remembrance, as a child, the first thing you ask any patient was that you take the language , Like this... It would be fantastic, wonderful that he could hear what you say now.

Eric Topol:
It is fabulous, I mean, the perfect time has come to do things in a different way in medicine because, from an economic point of view, We are in a desperate situation but, from the technological point of view, It is the most extraordinary time that we have ever lived.

Rtve.es [en línea] Barcelona (Spain): rtRTVE.es21 of July 2011[REF. 6 March of 2011] Available on Internet:

http://www.rtve.es/television/20110304/redes-lugar-enfermedades-cuidar-salud/413509.shtml

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eLEGS allows the paraplegics to stand and walk

18 07 2011

Berkeley Bionics ™, Developer and American manufacturer of Bionic exoskeletons that increase human force, the strength and mobility, He has presented eLEGS, a Bionic device that allows paraplegics to walk and walk.

eLEGS You can adjust and adaptCSR to the majority of people in a matter of minutes. Users can auto - transfer from their wheelchair to the device, it attaches to the body with simple straps and clips. It may be placed on the clothing and shoes and, with a little practice, its users are able to put it on and take it off in one or two minutes.

eLEGS It offers an unprecedented knee flexion, It translates in a way more natural gait, so it can be handled in mixed terrain. Your speed depends on the fitness of each patient and their status. The device works with battery and has a computer that, using sensors, There are the gestures that the user performs to determine their intentions and then acts accordingly.

Clinical trials will begin early next year at the United States rehabilitation clinics. The patients selected will have the opportunity to enroll in a training program eLEGS under medical supervision. Therapists who are responsible for the program will receive training before attending patients.

Scope.NET [en línea] Spain: scope.NET, 18 in July of 2011, [REF. July of 2011] Available on Internet:

http://www.scop.net/scope-technology/e_leg.php



A study shows that you can delete traumatic memories in mice

14 07 2011

Two researchers of the Johns Hopkins University in Baltimore (United States) they have carried out an investigation which demonstrates that it is possible to permanently delete traumatic memories in mice. The experiment, focused on the analysis of a protein in the region of the brain responsible for remember the fear, You can contribute to improve the treatment of pathologies of the behavior as, for example, post-traumatic stress disorder.

Richard L. Huganir, Professor and director of Neuroscience at the Johns Hopkins University in Baltimore (United States).

When a traumatic event occurs, creates a terrible memories that can last a lifetime a person and who has a debilitating effect on health. The possibility of eliminating the effects of this type of memories in mice has been the subject of research carried out by Richard L. Huganir, Professor and director of Neuroscience at the Johns Hopkins University in Baltimore (United States), and Roger Clem, postdoctoral fellow. Their research describes the molecular and cellular mechanisms involved in this process and raises the possibility of using drugs to enhance the behavior therapy.

The study focused on the nerves of the amygdala circuits, the part of the brain responsible for processing and storing of emotional reactions, as fear, in humans and animals. The scientists exposed a set of mice to a strong and sudden sound to cause them to fear and could observe that certain cells of the amygdala behaved differently after each broadcast of sound.

The analysis of this phenomenon allowed the discovery of temporary amount of protein increases, especially the AMPAR permeable to calcium, a few hours of fear conditioning. The data showed that the highest value of proteins was 24 hours after cause the feeling of fear and it disappeared after two days.

As these proteins in particular are especially unstable, scientists expected that memories of fear could be permanently deleted through a combination of behavior and the Elimination of the AMPAR protein therapies, and thus weaken the connections in the brain created by trauma, selectively deleting episodes of memory.

Gencat.cat [en línea] Spain: geGencat.cat14 in July of 2011, [REF. 22 in December of 2010] Available on Internet:

http://www.gencat.cat/diue/noticies/10754410.html



Daniel Kraft: The future of medicine?? There is an application for that

11 07 2011

Dr. Daniel Kraft

Daniel Kraft is a physician and scientist trained in Stanford and Harvard, with more than 20 years of experience in clinical practice, biomedical research and innovation. Dr. Kraft directs the medicine program in the Singularity University and is the executive director of FutureMed, a program that explores technologies developed and converging exponentially and its potential in biomedicine and health.

In TEDxMaastricht, Daniel Kraft offers a quick look at the years of innovations in medicine, driven by new tools, testing and applications that provide information of diagnosis to the patient stretcher.

 

Ted.com [en línea] USA: ted.com, 11 in July of 2011, [REF. June of 2011] Available on Internet:

http://www.ted.com/talks/lang/eng/daniel_kraft_medicine_s_future.html



Ideas in health, with the seal of the ' spin-off’ Topping, start your health projects 2.0

7 07 2011

A 30% Spanish patients look up information about diseases on the Internet and, Although there is much noise information, “with a little common sense can be found in the network reliable and rigorous information that helps us to improve our quality of life”, explains Armando Ruiz, Director-general of Topping, a spin - of(f) located on the Parc de Recerca UAB (PRUAB) specialized in the development of clinical research projects, scientific dissemination and communication in health for companies and institutions.

Armando Ruiz and Topping equipment, a ' spin-off’ created in 2007 in the Universitat Autònoma de Barcelona – Photo: © Topping.

These routines, derived from the proliferation of new technologies, they have resulted in the birth of medicine 2.0 and the so-called e-pacientes, players who create a new way of understanding medicine, making participatory and translational, where both doctors and patients have much to say.

The project Ideas in health, developed by Topping and financed by the Spanish Foundation for science and technology (FECYT), has been created with the aim to seek new forms of collaboration among physicians, researchers and e-pacientes to move forward in the knowledge and the implementation of the results of research related to asthma and chronic obstructive pulmonary disease (COPD), cancer, diabetes and cardiovascular diseases, neurodegenerative, rare and skin. The dissemination of this information society is via the web http://ideasensalud.com/ (with news, interviews, videos, among others). It is a medical website accredited by the Col·legi Oficial de Metges de Barcelona (COMB).

Part of this informative line, Ideas on health promotes the development of their own collaborative research projects. Currently, According to Armando Ruiz, they are working on a project related to COPD and another with allergies and food intolerances. These projects are carried out together with the Spanish Association of patients and relatives of COPD (ASOCEPOC) and the Spanish Association of allergic to Latex and foods (AEPNAA).

To attract financing for companies and individuals, Ideas in health has the support of the new platform marquetry the Ministry of science and innovation.

Biocat.cat [en línea] Spain: biocat.cat, 7 in July of 2011, [REF. 30 in June of 2011] Available on Internet:

http://www.biocat.cat/es/noticias/ideas-en-salud-creado-por-la-spinoff-topping-inicia-sus-proyectos-de-salud-20



Dr FRANGI: HPV Institute to promote integrated biomedical research is now operational

4 07 2011

Dr. Alejandro Frangi

Director Center for research in image technologies and biomedical simulation (CISTIB)

In June, in Belgium, gave the kick-off of the non-profit foundation HPV Institute, of which belongs to Pompeu Fabra University and is a member in the Steering Committee.

The great challenges of the health care system for the next decade - as personalized medicine, the ageing of the population, migrations and mobility, systems of prevention and early diagnosis or overcoming chronic diseases, among others- they will require the kind of integrated research HPV initiative want to promote.

The Virtual Physiological Human Institute for Integrative Biomedical Research, abbreviated form, HPV Institute, became the 24 March of 2011 in Leuven (Belgium), the process of incorporation and the month of June ended in mid May, in Belgium, It began to operate as a non-profit organization.
Alejandro Frangi, Professor and researcher ICREA-Academia of the Department of information and communications technologies (DTIC) of the Pompeu Fabra University is part of the Steering Committee and the next 28 September is expected to be held the first General Assembly of the HPV Institute in the Pompeu Fabra University.

A consolidated action covering research and clinical practice

HPV Institute mission is to ensure that the vision of the Virtual Physiological Human is a reality, adopted internationally and effectively used both in clinical practice and research.

The HPV initiative was started in the year 2005, driven by a group of European researchers interested in applying predictive models to biomedicine. Inspired by the Physiome project, the HPV initiative focused on the development of methodologies and technologies that make it possible to investigate the human body as a whole.

The concerted action STEP He supported the realization of the first roadmap of research carried out in the framework of this project, involving more than three hundred experts from around the world. From there, the HPV community prospered quickly until reaching post more than two thousand researchers from around the world and over two hundred million in competitive research projects.

Currently HPV has the support of the 7 Sixth framework programme network of European excellence, in which UPF has played a fundamental role, with more than thirty research projects, that includes six major projects integrated with an important participation of UPF and other Catalan and Spanish actors.

An action that requires the sum of many knowledge

Life is the result of a complex system of interactions involving many processes that take place in different scales in space and in time. Biomedical research and clinical practice every day produce a lot of information about these processes. This information, However, is very fractional, (e) integrate it is one of the objectives of the researchers for which require tools to make it intelligible and that, In addition, grows exponentially in time.

So it is necessary to develop a new approach that allows to integrate all this information and at the same time simplifying it to transform it into knowledge. Virtual Physiological Human, HPV, It is a methodological framework that will make it possible to study the human body as a whole once properly established and validated.

For this reason, the HPV initiative requires multidisciplinary contribution of different fields of knowledge, as mathematics, Computational Sciences, Physics, Chemistry, Engineering, Biology, the physiology and medicine.

In the short and medium term, the need to consolidate an integrated biomedical research will also require the consolidation of an academic curriculum, the publication of scientific journals and the establishment of international conferences, scientific societies and international awards. There will, also, that demonstrate the efficacy of the developments based on the HPV paradigm in medical practice, and ensure the visibility needed both in the field of research and the society in general.