They regenerate tissue of the thyroid with embryonic stem cells of mice

28 02 2013

From pluripotent cells from embryos of rodents, a scientific team has managed to create in vitro thyroid follicles that, transplanted once, they have proven to be functional. Results, published in Nature, they may serve to apply regenerative medicine for the treatment of hypothyroidism.

 

Tinción de yodo (verde) expresado por los folículos tiroideos obtenidos in vitro a partir de células madre embrionarias de ratón. Imagen: S. Costagliola

Iodine stain (Green) expressed by the thyroid follicles obtained from mouse embryonic stem cells in vitro. Image: S. Costagliola

A group of researchers from Belgian and American centres achieved first convert embryonic stem cells of mice in the thyroid cells and form with them tissues that, Once transplanted in rodents, they were able to fulfill their mandate of regulating the hormonal levels of the animal.

Highlights of the study is that "follicular cells derived from embryonic stem cell generated tissue of the thyroid capable of recovering the hormonal deficits of animals".

A path opens to the application of stem cell technologies to treat the Hypothyroidism -the most common congenital endocrine disease in humans, that affects one of every 2.000 newborns-, an area of study that, so far, He has received little attention by the regenerative medicine.

The main function of the thyroid gland is to metabolize iodine synthesizing hormones that regulate growth, development and metabolism of almost all tissues.

In the case of mammals, This gland is composed of two types of endocrine cells: thyroid follicular cells - secreting two hormones, thyroxine and triiodothyronine - and C cells, You secrete calcitonin.

Sabine Costagliola, of the Free University of Brussels, and his colleagues created a protocol to generate embryonic stem cells from thyroid follicular cells, due to overexpression of only two transcription factors - proteins that are involved in the expression of genes-.

In the next step applied to new follicular cells treated with hormone thyrotropin - a drug used to treat thyroid cancer -. Thyrotropin encouraged the cells to form three-dimensional tissues, that is to say, follicles in vitro created were obtained.

Finally, When transplanted follicles in mice with hypothyroidism, the animals recovered their hormone levels, implying that thyroid tissues derived from stem cells fulfilled its function.

 

Bibliographic reference:

Francesco Antonica, Dominika Figini Kasprzyk, Robert Opitz, Michelina Iacovino, Xiao-Hui Liao, Alexandra Mihaela Dumitrescu, Samuel Refetoff, Kathelijne Peremans, Mario blanket, Michael Kyba, Sabine Costagliola. "Generation of functional thyroid from embryonic stem cells". Nature. DOI:10.1038/nature11525. Vol. 490. 10 October of 2012.

 

 

Agenciasinc.es [en línea] Madrid (ESP): agenciasinc.es, 28 de febrero de 2013 [REF. 10 October of 2012] Available on Internet:http://www.agenciasinc.es/Noticias/Regeneran-tejido-del-tiroides-con-celulas-madre-embrionarias-de-ratones



Medical applications of Mussel adhesive proteins.

25 02 2013

When it comes to energy to adhere in wet conditions, Marine mussels are difficult to overcome, since they can stick to virtually all organic and inorganic surfaces and maintain saltwater, including tide turbulent environments. This Mussel adhesive protein has served as inspiration to scientists for biomedical applications, as the delivery of drugs, surgical repair and cancer drugs.

Foto: TAMORLAN

Photo: TAMORLAN

In particular, have been created new materials that mimic for three medical applications Mussel adhesive proteins: sealants for fetal membrane repair, the autoconfiguration of antibacterial hydrogels and polymers for the delivery of drugs against cancer and the thermal destruction of cancer cells.

Phillip B. Messersmith, Professor of biomedical engineering at the McCormick School of engineering and applied sciences of the Northwestern University, in United States, discuss your research here at the Symposium ‘ the translation of accession Mussel beneficial to new concepts and materials’ to be held at the annual meeting of the American Association for the advancement of science (AAAS) that takes place these days in Boston.

“The accession of the mussel is a remarkable process that involves the secretion of a protein of liquid adhesive that hardens quickly in a solid, water resistant adhesive– explains Messersmith–. Various aspects of this process inspires our development of synthetic materials for practical applications. An unusually compelling opportunity for the translation of the concepts of Mussel adhesion is in the repair or reconstruction of tissues in the human body, where water is ubiquitous and their presence represents a challenge to achieve the desired results”.

The foot of the mussel (Mytilus edulis) It produces a sticky glue to adhere to rocks and other objects and their key is a special protein family, so-called Mussel adhesive proteins, containing a high concentration of DOPA amino acid catecolico (dihydroxyphenylalanine). All biomedical materials created by Messersmith contain a synthetic form of DOPA, a synthetic polymer with a DOPA simple that it was first developed in 2002.

For the fetal membrane repair, that it may break prematurely spontaneously or by a surgical procedure, that often leads to premature delivery, preterm birth and other serious complications, synthetic polymer Messersmith is formulated as a liquid glue which solidifies rapidly to adhere to moist tissue and seal defects fetal membrane. His group is working with researchers in Europe to carry out tests in vivo of their sealants doctors inspired by mussels for fetal membrane repair.

In the case of the antibacterial hydrogels AutoFit, Messersmith employs silver both to induce cross-linking Hydrogel by means of oxidation of catechol and as a precursor to the formation of silver nanoparticles, embedded within the structure of the Hydrogel and it releases silver ions to produce an antibacterial effect. The silver ions possess antibacterial activity at low concentrations, and this has led to an interest in the incorporation of medical devices silver.

The synthetic adhesive to the administration of drugs against cancer and disposal destruction of cancer cells consists of polymer to form sensitive vehicles to pH for supply of drugs that are stable and inactive in the bloodstream, but are activated in the environment of the acid tumor, releasing the drug.

A second design is to modify the surface of nanorods of gold with a coating of polymer that helps target cells and that, Once on the target, the nanorods are radiated with near-infrared light to produce a very localized heating that thermally destroys cancer cells.

 

 

Europapress.es [en línea] Madrid (ESP): europapress.es, 25 de febrero de 2013 [REF. 16 de febrero de 2013] Available on Internet:http://www.europapress.es/salud/noticia-pegamento-mejillon-inspira-cientificos-reparacion-quirurgica-20130216153202.html



UCI’s iMedEd Initiative named a 2012-13 Apple Distinguished Program

21 02 2013

School of Medicine’s all-digital, iPad-based curriculum mirrors new age of patient care.

Steve Zylius / University Communications

Steve Zylius / University Communications

 

Irvine, Calif., Feb. 11, 2013 — The iMedEd Initiative – UC Irvine’s innovative medical education program based on iPad tablet computing – has been chosen as a 2012-13 Apple Distinguished Program.

This year, iMedEd Initiative joins select programs that Apple is honoring nationwide as exemplary learning environments. The Apple Distinguished Program designation is reserved for programs that integrate Apple technology into education and meet criteria for visionary leadership, innovative learning and teaching, ongoing professional learning, compelling evidence of success, and a flexible learning environment.

“The iMedEd Initiative has been selected as an Apple Distinguished Program for its innovative, digital-based educational platform that conforms to the 21st century learning styles and needs of students throughout the world,” said Dr. Ralph V. Clayman, dean of the UC Irvine School of Medicine.

The iMedEd Initiative is reinventing the traditional medical school curriculum, Clayman added. It was the first in the nation to build a completely digital, interactive learning environment – which includes tablet-based learning and portable ultrasound clinical training – and continues to lead in adapting emerging technologies for all aspects of classroom and clinical training.

Since 2010, when the initiative was launched, incoming UC Irvine medical students have received fully loaded iPads, putting at their fingertips all the information they need to read, study or review. (Textbooks are electronically accessible or carried directly on iPad.) The tablets also provide podcasts of lectures and a wealth of other instructional materials assembled for students’ course and clinical work. This multimedia approach has engendered a rich educational environment that accommodates all modes of learning, especially small group sessions.

With their secure iPads, students record and display data from digital stethoscopes, bedside diagnostic ultrasound units and a variety of other medical devices, as well as encrypted, patient-protected electronic medical records.

“At UC Irvine’s School of Medicine, we see each of our talented students as having a unique style of learning. It’s our challenge and responsibility to provide a broad array of educational opportunities so that every student can master the knowledge essential to becoming an outstanding healthcare provider,” Clayman said.

“The digital platform has enabled us to effectively respond to this responsibility in a manner heretofore unimaginable. By having all aspects of our medical school curriculum on iPad, learning becomes a 24/7 opportunity no longer tied to the classroom or a desk. We believe our students are learning better than they have in the past.”

He added that the first class participating in the iMedEd Initiative scored an average of 23 percent higher on their national exams – taken at the end of the second year of medical school – than previous UC Irvine medical school classes, despite having similar incoming GPAs and MCAT scores.

UC Irvine’s medical students have advanced the iMedEd mission in creative ways. They formed an iMedEd Innovators Group, which consists of eager “technophiles” who review the latest technology offerings to see what place they might have in the medical school curriculum. Their blog is read worldwide.

In addition, with support from the Kay Family Foundation, students from the medical school and the Donald Bren School of Information & Computer Sciences teamed up to hold the world’s first student-run Med AppJam, designed to create Apple-based applications with healthcare utility. Over the course of 10 days, more than 100 participants produced 19 apps – among them one focused on acute care during natural disasters and another that provides instruction for bedside diagnostic ultrasonography.

Other students have formed an iMedEd International program, exploring how their iPads and SonoSite portable point-of-care ultrasound units can be used to improve healthcare and medical education in Peru, Australia, China, Viet Nam, Nicaragua, India and Israel.

“Our students’ enthusiasm and willingness to discover new learning modalities is unparalleled, and they are key to the success of iMedEd,” said Dr. Warren Wiechmann, an assistant clinical professor of emergency medicine and faculty director of the Instructional Technologies Group, which oversees iMedEd. “It’s extremely gratifying to see our students apply technology in innovative ways because we strongly believe that familiarity and comfort with technology will be essential for them to be skilled physicians in this new digital era of medicine.”

The iMedEd Initiative is fully supported by the John and Mary Tu Scholarship Fund, which finances the purchase of next-generation iPads and a complete library of electronic textbooks for all incoming UC Irvine medical students. A plaque presentation for the Apple Distinguished Award will take place today at 2 p.m. at the UC Irvine Medical Center.

About the University of California, Irvine: Founded in 1965, UC Irvine is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UC Irvine is among the most dynamic campuses in the University of California system, with more than 28,000 undergraduate and graduate students, 1,100 faculty and 9,400 staff. Orange County’s second-largest employer, UC Irvine contributes an annual economic impact of $4.3 billion. For more UC Irvine news, visit news.uci.edu.

News Radio: UC Irvine maintains on campus an ISDN line for conducting interviews with its faculty and experts. Use of this line is available for a fee to radio news programs/stations that wish to interview UC Irvine faculty and experts. Use of the ISDN line is subject to availability and approval by the university.

 

 

News.uci.edu [en línea] Irvine, CA (USA): news.uci.edu, 21 de febrero de 2013 [REF. 11 de febrero de 2013] Available on Internet:http://news.uci.edu/press-releases/ucis-imeded-initiative-named-a-2012-13-apple-distinguished-program/



Controversias en un nuevo tratamiento oncológico: Dicloroacetato (DCA)

18 02 2013

 

Scientists of the University of Alberta, in Canada, They claim to have discovered a substance that kills cells affected by tumors, but they don't get funds to continue its testing because the substance used is not patentable.

Researchers at the University of Alberta have managed to cure cancer using a drug called dichloroacetate, However, as this substance does not require patent and is cheap compared with the drugs used to fight cancer by the large pharmaceutical companies is research has not received much support or it is echoing in the media, Perhaps blocked by the same pharmaceutical.

Canadian scientists tested the dichloroacetate in human cells and noticed that it kills the cells of cancer in the lungs, in the brain and chest, leaving only the healthy cells. In rats with severe tumors cells shrug to be supplied with this substance water.

Dichloroacetate triggers an action in the mitochondria so this finishes naturally with cancer cells (traditionally focuses on Glycolysis to combat it).

Dr Michelakis of the University of Alberta expressed concern of not finding funds for clinics with dichloroacetate testing since it would not represent strong gains for investors private not be patented.

This fits exactly with what said the prize Nobel of medicine Richard J. Roberts in this interview about how drugs that cure are not profitable and that are not developed by pharmaceutical companies that instead Yes develop drugs cronificadores that are consumed in serialized form.

 

INTERVIEW WITH THE NOBEL PRIZE OF MEDICINE RICHARD J. ROBERTS

The research you can plan?

If I were a Minister of science, It would seek to enthusiastic people with interesting projects; It would give them the right money so no they could do nothing more than investigate and let them work ten years ago to surprise us.

It seems a good policy.

Usually believe that, to go very far, you have to support the basic research; But if you want more immediate and cost-effective results, You must bet on the applied...

And it is not?

Often, the more profitable discoveries have been made from very basic questions. Thus was born the gigantic and billion dollar industry U.S. biotech for which I work.

How you born?

Biotechnology arose when passionate people began to ask if he could clone genes and to study them and try to purify them.

A real adventure.

Yes, but no one expected to grow rich with these questions. It was difficult to obtain funds to investigate the answers until Nixon launched the war against cancer in 1971.

It was scientifically productive?

It allowed, with an enormous amount of public funds, much research, like mine, It served not directly against cancer, but it was helpful in understanding the mechanisms that enable the life.

Found what you?

Phillip Allen Sharp and I were honoured for the discovery of introns in DNA eukaryotic and mechanism of gene splicing (splicing of genes).

What you served?

This discovery allowed to understand how DNA and, However, It has only an indirect relationship with cancer.

Do research model seems more effective, the American or the European?

Is obvious that the American, in which takes part activates private capital, is much more efficient. Take for example the spectacular advance of the computer industry, where is the private money that funds basic and applied research, But regarding the healthcare industry... I have my reservations.

I hear you.

Research in human health not can depend on just economic profitability. What is good for the profits of the companies not always is good for people.

Explained.

The pharmaceutical industry wants to serve capital markets...

Like any other industry..

It is not any other industry.: We are talking about our health and our lives and our children and millions of human beings.

But if they are profitable, better research.

If you only think of the benefits, you stop worrying about serve human beings.

For example...

I checked and in some cases dependent on private funds researchers have found very effective medicines which had finished completely with a disease...

And why they cease to investigate?

Because drug companies are often not so interested in heal you and make money, so that research, suddenly, It is then diverted to the discovery of medicines that do not cure all, but chronic disease and make you experience an improvement that disappears when you stop taking the medication.

This is a serious accusation.

As it is usual that the pharmaceutical companies are interested in lines of investigation not to cure but only for cronificar problems with drugs more profitable cronificadores that those who heal all and once and forever. And you don't have more to follow the financial analysis of the pharmaceutical industry and will check what I say.

There are dividends that kill.

Why you say that health cannot be one market more or can be understood only as a means to earn money. And why I believe that the European model of public and private capital is less easy it conducive to that kind of abuse.

An example of such abuse?

They have been investigating antibiotics because they are too effective and completely healed. As no new antibiotics have been developed, infectious microorganisms are becoming resistant and today tuberculosis, that in my childhood had been defeated, It is resurfacing and he killed this last year to one million people.

Do not you speak me of third world?

That is another sad chapter: hardly the third world diseases are investigated, because drugs that combat them wouldn't be profitable. But I'm talking about you our first world: medicine that cures all isn't profitable and therefore not investigated it.

Do politicians not involved?

Do illusions: in our system, politicians are mere employees of big capital, you invest enough out the elected his boys, and if they do not leave, they buy to those who are elected.

Everything will be.

The capital only interested in multiply. Almost all politicians - and I know what I mean- blatantly they rely on the pharmaceutical multinationals that finance their campaigns. The rest are words...

 

Richard J. Roberts was born in Derby, England, in 1943. She initially studied chemistry, then moved to United States, where it develops teaching at Harvard and at the Cold Spring Harbor Laboratory in New York. From 1992 He directs research at the Biolabs Institute, Beverly, (Massachusetts).

He won the Nobel Prize for Physiology and medicine in 1993, shared with Phillip. Sharp, for his work on introns, fragments of DNA that has nothing to do with genetic information. They could describe the information in a gene was not prepared on an ongoing basis, but that was split.

The first experiments were carried out on genetic material from viruses, particularly adenovirus.

Both came to the conclusion that the RNA has had to precede the DNA in the evolution.

 

CURE FOR CANCER: TO PHARMACEUTICAL COMPANIES NOT YOU ARE INTERESTED IN

Translated by chemtrails Seville It is a very simple technique using a single drug. The method employs dichloroacetate, and is currently used for the treatment of metabolic disorders. It is therefore, There is no concern of side effects or long-term effects.

This medication does not require a patent, so anyone can use it widely and cheaply compared with the expensive medicines against cancer produced by the major pharmaceutical companies.

Canadian scientists tested the dichloroacetate (DCA) in humans, killing cancer cells in the lung, moms and even cancer cells in the brain without attacking healthy cells. It was tested on rats with induced serious tumors, their cells were reduced when they were fed water supplemented with DCA (dichloroacetate). The drug is widely available and the technique is easy to use, why the most important pharmaceutical companies aren't involved? or do the media aren't interested in this discovery?

In the human body the fight against cancer is made against a cell type, the mitochondria, but they have to be activated to be effective. Scientists thought that these mitochondrial cells were damaged and were therefore ineffective against cancer. So they focused on using Glycolysis, It is less effective to cure cancer and one waste more. Pharmaceutical companies focused on the method of Glycolysis to fight cancer. Dichloroacetate in addition does not depend on Glycolysis, in mitochondria, allowing it to fight cancer cells.

The side effect of this is that it also reactivates a process called apoptosis. As you can see, the mitochondria have an important self-destruct button that can not be activated in cancer cells. Without it, the tumors would grow and cells refuse to die. Fully functioning mitochondria, Thanks to DCA (dichloroacetate), they can go to die.

Without the Glycolysis, the body produces less lactic acid, so the tissue around the cancer cells does not decompose as a seed for new tumors.

Pharmaceutical companies are not investing in this research because the method of the DCA cannot be patented, without a patent can not make money, as they are doing now with their patents of AIDS. Given that pharmaceutical companies will not develop this drug, the article says that other independent laboratories should begin to produce this drug and do more research to confirm all the conclusions and produce drugs. All bases can be made in collaboration with universities, will be happy to help such research can develop an effective drug to cure cancer.

This article seeks to highlight this study, We hope that some independent companies pick up this idea and produce these drugs, Since corporations will not do it for a long time.

Source: HubPages.com

 

 

 

The main ingredient in healing - dichloroacetate (also known as acid DCA) the family of the acid haloaceticos. Here is the definition of acids haloaceticos:

"A family of organic compounds based on acetic acid molecule (CH3COOH), where are one or more hydrogen atoms attached to carbon atoms replaced by a halogen (chlorine, bromine, fluorine, and / or iodine). There are nine species of AHA including Monochloroacetic (AMCA), DCA (DCAA acid), and dibromoacetico (acid DBAA). AHA acids are colourless, they have a low volatility, they dissolve easily in water and are quite stable: "Source of GreenFacts”.

What gland controls metabolism in the body? The thyroid gland! Iodine is a necessary nutrient required by the thyroid gland to make thyroid hormone. Iodine is part of the molecule of dichloroacetic acid! in the form of dichloroacetate DCA is what is used to kill cancer!

Iodine plays an important role to keep the cells under control so that they do not grow out of control. Cancer cells are cells that are still growing and not die (Therefore appear lumps or tumors).

Iodine deficiency seems a logical explanation for cancer!

Coincidentally, Japanese women have lower rates of breast cancer, endometrial and ovarian cancer, as well as fibrocystic breast disease. Imagine! Their diets contain iodine by fish and algae!

Iodine is a detoxifying body! It has been shown that the body detoxifies harmful substances out of the body such as expelling: Bromine, Fluoride, Chlorine, Mercury, Lead, Cadmium or aluminium.

Iodine was once a common ingredient in many foods like bread. In the Decade of 1980, iodine withdrew from our breads and replaced with bromine. Bromine worsens the problems of iodine deficiency, Since it inhibits the absorption of iodine in the body! It is also a known carcinogen.

Iodine deficiency has been linked to the following diseases: Thyroid disease, prostate cancer, cáncer de mama, ovarian cancer, endometrial cancer, ovarian cysts, fibrocystic disease, Fibromyalgia.

Info wars

 

Sources:

http://www.vanguardia.com.mx/investigadoresencuentrancuraparaelcancerperonoesnegocioparafarmaceuticasyquizanuncavealaluz-724971.html

http://www.vanguardia.com.mx/cura_del_cancer:_A do bloqueada_por_las_farmaceuticas?(entrevista_con_el_dr._michelakis) _ - 731485.html

http://www.elmartillojudicial.com.ar/2011/05/16/investigadores-de-la-universidad-de-alberta-en-edmonton-canada-encontraron-la-cura-del-cancer-la-semana-pasada-sin-embargo-no-ha-sido-cubierto-en-las-noticias-o-en-la-television/

 

 

Haycomprension.blogspot.com.es [en línea] Unknown (unknown): haycomprension.blogspot.com.es, 18 de febrero de 2013 [REF. 20 de febrero de 2012] Available on Internet:http://haycomprension.blogspot.com.es/2012/02/cientificos-de-la-universidad-de.html



As it spreads antibiotic resistance

14 02 2013

"An apocalyptic threat". So Dame Sally Davies, the consultant Ministry of health Briton, He called the problem of resistance submitted by bacteria to antibiotics in a speech to Parliament. A problem, This, increasingly widespread in hospitals around the world caused by the over-use of antibiotics and exacerbated by the bacteria's ability to transmitted other genes that make them resistant to the medications used. Faced with an enemy as adaptable to what you can do? One strategy would be to prevent bacteria from exchanging genes with which defend themselves by antibiotics. In this optic ’, a study published in Pnas a team of American researchers has identified the molecular mechanism by which the antibiotic resistance is passed from one bacterium to another and showed that blocking this pathway can reduce the ability of bacteria to become resistant to medicines.

 

For their experiments scientists atUniversity of North Carolina they used certain strains of Staphylococcus aureus, antibiotic resistant Vancomycin, also known as Vrsa (mycin-resistent S. aureus). The S. aureus is a common bacteria found on the skin, that can cause infections in humans, usually treated with antibiotics such as Penicillins. Are part of this family even the infamous Mrsa (S. aureusMethicillin-resistant)become one of the main causes of hospital infections, so far only effectively treated with Vancomycin.

"We focused on Vrsa to trying to understand how is acquired resistance to Vancomycin”, explains Jonathan Edwards, the first author of the study: “why this strain was isolated the first genetic element that confers resistance to this antibiotic ". It is a circular Dna fragment, the plasmid pLW1043, that during the process of conjugation - in which two bacteria come in contact and exchange genetic material – is transferred from one organism to another. The pLW1043 plasmid contains genes necessary for survival in the presence of antibiotic It requires the action of a protein in order to transfer from one bacterium to another ’: theNes or nicking enzyme, that allows the mobilisation process, cutting the plasmid Dna in bacteria and donor rilegandolo in that case transfer receiver.

Using data of Crystallography and x-ray diffraction, to determine the three-dimensional structure of a protein, researchers have identified two key regions for the functioning of the enzyme ’, forming an area in which the plasmid containing genes for resistance is changed to be transferred. If the structure of this region change, or if it prevents it from binding to Dna, crashes the plasmid transfer from one bacterium to another. In fact, based on the Crystal structure of Nes, scientists have designed a synthetic polymer polyamine's able to bind specifically to plasmid Dna by preventing the action of Nes and ’ have observed a reduction of about 90% enzymatic activity.

"This result is really promising-says Edwards – why could lead in future to the development of new methods to block the propagation of antibiotic resistance by inhibiting the transfer of resistance genes from one bacterium to another".

Experts say the problem of antibiotic resistance is one of the greatest risks to human health, a veritable health emergency Global. Infections that do not respond to antibiotic treatment used so far, such as tuberculosis, the Mrsa and gonorrhoea, are on the rise. And becomes increasingly long and expensive produce new antibiotics. Therefore, According to theOms, until the search will not find a better solution,the only chance to stem the spread ofantibiotic resistance are better hygiene and more conscious use of antibiotics.

 

References: PnasDOI:10.1073/pnas. 1219701110

Image Credits: estherase/Flickr

 

 

Galileonet.it [en línea] Rome (ENG): galileonet.it, 14 de febrero de 2013 [REF. 30 in January of 2013] Available on Internet:http://www.galileonet.it/articles/5108dd03a5717a30680000c4



Health documentary about the end of life

11 02 2013

Under the title ‘ of death we are all ’, the production has been widely accepted in social networks and in national and international forums.

 

The documentary ‘ death we are all ’ reflected through first-person testimonials how to die the Andalusians and do have family and people carers about the attention they receive patients at the end of life. Almost a year after its presentation in the days of quality and dignity to dying, held in the Andalusian School of public health (EASP), the video It has received about 4.000 visits, with a great acceptance in social networks and in other fora and seminars both nationally and internationally.

This video was created precisely with the idea “provide elements for reflection on a fairly taboo in our society as it is death”, explained Maite cross Piqueras, the EASP technique and video Coordinator, made in turn by the anthropologist Marina Pérez Trigueros.

The first additional provision of the Law 2/2010 of 8 April rights and guarantees of the dignity of persons in the process of dying urged the Ministry of health and Social Welfare of the Junta de Andalucía to prepare, “within the period of one year, a study on how to die the Andalusians in order to assess regularly the implementation and impact of this law”, explained Cruz. To gather information on the effects that this law was having among the Andalusian citizens, raised a research with qualitative methodology. The objective of this research was to evaluate, from the perspective of family members and caregivers, the care received by the patients at the end of life. To do this, they became 10 interviews in different parts of Andalusia and with different profiles of individuals and family carers of people.

Although in general family and caregivers appreciate care received, the documentary raises a number of demands and to improve aspects that can be summarized in the improvement of communication between patients, family members and healthcare professionals; reinforcing elements of privacy of the person who is going to die; disseminate and clarify concepts among the citizens concerning directives or palliative sedation.

 

Broadcasting

Normally, at the conclusion of an investigation, the results are disseminated through publications of scientific character and, If possible, with impact factor. In this case, This video is intended to publicize the results of an investigation through a different format as the video and introduce elements for reflection on the end of life.

“When death becomes inevitable and in this battle (as recites the poet and musician Gil Scott-Heron at the end of the video) Science has little to say, film resources, poetry or literature help us better understand the pain, suffering and death”, concludes Maite Cruz.

After the presentation in the days of quality and dignity in dying and its dissemination through social networks, the video has also screened at the 12th Colloquium of the network of medical anthropology (REDAM) about ‘ new social and cultural trends of death’ and the I shows for documentaries of the V Congreso Iberoamericano de qualitative health research carried out in Lisbon last October. Also, the video will be presented at the next seminar of ‘ culture, health and cinema ’, organized by the Seminari Permanent de Recerca i Comunicació Científica - SPRICC- E.U. Nursing Gimbernat, attached to the UAB (Autonomous University of Barcelona) to be held in Barcelona the 6 March of 2013.

 

Video documentary presented the 9 de febrero de 2012 on the day of quality and dignity in dying,coordinated by Maite cross Piqueras, Andalusian School of public health, and performed by Marina Pérez Trigueros. See here.

 

Juntadeandalucia.es [en línea] Seville (ESP): juntadeandalucia.es, 07 de febrero de 2013 [REF. 30 in January of 2013] Available on Internet: http://www.juntadeandalucia.es/presidencia/portavoz/sociedadysalud/075465/muerte/digna/salud/sanidad/video/easp/documental



New alloy of magnesium for biomedical applications

7 02 2013

Scientists from the departments of physics and cell biology of the Autonomous University of Barcelona (UAB) as well as the Catalan institution for research and advanced studies (ICREA) they have developed a new magnesium alloy non-cytotoxic with better mechanical properties and better performance against corrosion through the addition of a small amount of Palladium. This new alloy has a potential application as biodegradable implants.

Microestructura de la aleación de Magnesio y Paladio

Microstructure of the alloy of magnesium and Palladium

References

S. González, E. Pellicer, J. Fornell, A. Blanquer, L. NeighborhEods, E. Ibanez, P. SolsSna, S. Suriñach, M. (D). Baro, (C). Nogués, J. Sort. "Improved mechanical performance and delayed corrosion phenomena in biodegradable Mg-Zn - Ca alloys through PdJalloying". J. Mech. Behav. BioMed. Mater. 6 (2012) 53-62.

Currently there are different metallic materials for biomedical applications such as steels, titanium alloys, etc. These alloys can be used, for example, as implants because they allow high loads and do not present an excessive deformation nor permanent dimensional changes. Despite its frequent use, These alloys have a superior to human bone rigidity so that the bone can suffer reabsorption, cell death as well as that the implant may loosen. The problem of bone absorption (mass loss) It is similar to which suffer the astronauts in space. This loss happens because a lack of gravity prevents the bone to fulfil its function of supporting the weight of the body. This limitation can be overcome using magnesium alloys since they present little stiffness. Is more, magnesium alloys have good biocompatibility and biodegradable (non-toxic materials that are reabsorvidos by the human body after a certain time), which is a great advantage because it avoids the need to remove the implant body after a patient has recovered. However, the problem of some magnesium alloys is the high corrosion rate which presented in physiological conditions, which makes these alloys degrade until the bone is repaired. For this reason it is important to decrease the speed of degradation of alloys of magnesium. our work shows how a proper and effective way of delaying the start of corrosion is alloying magnesium with PD as evidenced by the displacement of the potentials of corrosion to more positive values. This sample corroded surface is also smoother and presents fewer cavities. The Palladium has been used for many years as a main element in dental alloys because of its high resistance to corrosion and low toxic activity. Like this, by controlling the concentration of Palladium in alloy, We can control the speed of degradation of the implant, doing these will degrade when the bone is recovered. initial magnesium alloy microstructure, which consists of small scattered crystals in an amorphous matrix, It changes dramatically when you add a small amount of Palladium because this is sufficient to form a fully crystalline microstructure (Figure). From nanoindentation studies we have seen how the addition of this element increases the hardness of the alloy as well as resistance to wear. Resistance to wear is interesting since it prevents the formation of remains from the wear and tear that may cause reactions inflammatory. cytotoxicity tests do not show a significant increase in the number of dead after being cultured cells during 27 hours, which confirms that this alloy is not cytotoxic and that therefore can be used potentially as biodegradable implants

Sergio González, Eva Pellicer

Department of physics

Sergio.Gonzalez@uab.cat; Eva.Pellicer.icn@uab.cat

 

Uab.es [en línea] BellaTerra (ESP): @UAB.es, 07 de febrero de 2013 [REF. may of 2012] Available on Internet: http://www.uab.es/servlet/Satellite?CID = 1096481466568&pagename = UABDivulga % 2FPage % 2FTemplatePageDetallArticleInvestigar&param1 = 1337150371986



The crisis of the Catalan Health System

4 02 2013

Manel Balcells, MD

Director of the’ Knowledge area Health Consortium of terrace

 

 

The intense economic crisis we suffer in Europe, about anything, the countries of southern, has put in evidence, the fragile balance of a health system, It boasts a very competitive quality, but he has questioned its sustainability in an insistent.

Historically, He has talked of a differentiated model Catalan health, the result of the own tradition of having a concerted hospital network (XHUP), a high percentage of population with a mutual assurance, and a large presence of our professionals in the networks of excellence·excellence in biomedical research at the international level.

So very obvious that health spending by myself was inhabitant, the percentage of GDP devoted to health care, It was and is frankly less than the European average.

 

At the time of great current economic crisis where the cut in health care has gotten so much obvious, it becomes necessary to reframe a model that cannot endure more thinning is not with structural changes.

We make the crisis a chance.

The political crisis of the relationship with the State.

It's time to raise our national health system, and escape the inheritances, taking advantage of them but, What we want.

That is to say:

Perhaps the time has come to see as an "everything", health care, the Sanitaire, and the social.

Maybe, the time has come to understand the health system as a wealth generation, and structure in a system of national key knowledge transfer.

Perhaps the time has come to sort, the provision of services, with rationality and efficiency in each region.

Perhaps the time has come to clear out the terciarisme in the region of Barcelona.

Perhaps the time has come to open up the system towards a single public insurer, freedom of choice of the competition and generate.

Perhaps the time has come, to give way to the professionals in the field of clinical management.

Perhaps the time has come to add strategies in biomedical research related to the hospital sector.

Perhaps the time has come, then, to remake our model, desvinculant from Spain, and allow regular drug reference prices as well, the pharmaceutical policy, and our own portfolio of services.

The crisis of the system, required urgently, drawing, build, and develop our own model, foragitant the result of Franco that heritage pincers anachronistic managing the current Catalan Health Institute.

A public model, of quality, balanced and sustainable, copying the best of Nordic countries, with a holistic, far from hospital-centrisme, based on continuous innovation, and focused on the individual, It must be the duty of all the actors of the system over the next few months.

The health of all is at stake.