Discovered one of mechanisms favouring the aggressiveness of Ewing's Sarcoma

24 10 2013

Caveolin-1 is involved in the formation of new blood vessels around the tumor facilitating their growth and their proliferation the finding opens the door to new therapies against this childhood cancer research


Grupo de investigación en sarcomas

Research in Sarcoma group

Researchers at the Institute of biomedical research of Bellvitge (IDIBELL) led by the head of the research group in sarcomas, Oscar Martinez-Tirado, they have discovered one of the mechanisms that trigger angiogenesis (formation of new blood vessels) around the tumor cells of Ewing's Sarcoma, a very aggressive childhood cancer.

The results of the study, published in the journal PLoS ONE, they open the door to a new line of research of possible therapies for this tumor. Ewing's sarcoma is the second most common bone cancer and affects children and young people. Currently, If it is diagnosed early and doesn't metastasis, can be cured in the 80% cases between the 25% and the 30% cases are diagnosed when there is metastasis and survival drops to the 30%.


Angiogenesis and solid tumors

Angiogenesis is a key process in the growth, proliferation and migration of solid tumours. Tumor cells need new blood vessels that provide them with oxygen and nutrients extras need to be developed at a fast pace.

The Group of Oscar Martinez-Tirado has described in several studies functions of the protein caveolin-1 in Ewing's Sarcoma: “We have seen that it has a tumorogenico role in this type of tumor, to participate in the resistance to chemotherapy, It promotes metastasis and in this work we have shown that it plays a fundamental role in the angiogenic process”.

The researchers found that, in cell lines that are genetically modified to express not the caveolin-1, the tumors were smaller, they had more necrosis and Vascularity index was significantly more lower than in lines with caveolin-1. “It is therefore, a lack of caveolin-1 prevents the angiogenesis” He said Martinez-Tirado.

The researcher explained that although the caveolin-1 seems to be a possible therapeutic target for fighting Ewing's sarcoma, its location, It makes it very difficult to access "so have to find proteins that bind the caveolin-1 and they can take this role”.

In this sense, the study describes how the caveolin-1 interacts with another protein called EphA2 activating a signaling pathway that induces angiogenesis, more specifically the migration of cells that should form the vessels to the tumor. Said Martinez-Tirado “This protein is a membrane receptor that yes could be a good candidate to be therapeutic target”.


Possible future therapies

This finding opens the door to future potential therapies. “Now we have to study if in addition to being involved in angiogenesis, the EphA2 protein is tumorogenica per are. If it is not, We have the perfect target. "Our idea of the future is to be able to use this protein as a vehicle to release within the tumor cells toxic substances" explained Oscar Martinez-Tirado.

In this work the Hospital Vall researchers have also participated d ’ Hebron, University Hospital of Salamanca and San Joan de Déu Hospital in Barcelona.


The article reference

Sainz-marbled M., Huertas-Martinez J., Lagares-Tena L., Liberal J.M., Mateo-Lozano S., Alava E., C. Torres, Mora J., García del Muro X. and Martinez-Tirado O. EphA2-induced angiogenesis in Ewing sarcoma celles works through bGFG production is dependent on caveolin-1 and. PLoS ONE. August 2013 [en línea] Barcelona (ESP):, 24 October of 2013 [REF. 20 in August of 2013] Available on Internet: http://modul/noticies/es/598/descubierto-uno-de-los-mecanismos-que-favorece-la-agresividad-del-sarcoma-de-ewing



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