Minicerebros from stem cells

17 10 2013

Scientists develop minicerebros from stem cells


Human embryonic stem cell colony phase

Human embryonic stem cell colony phase


We have seen coronary tissue that beats, tracheae and bladders developed from stem cells. Now researchers have taken another step forward with the development of minicerebros from these programmable cells.


Are not really brains that work - in the same way that a car with the engine on the roof or wheels on the hood is not a vehicle that can lead- but the pieces are there, and is a major scientific advance, According to Juergen Knoblich, senior author of a new study on the use of stem cells for the development of brain tissue.


Scientists have created what they call “brain organoid” using stem cells. A pea-sized structures are made of human brain tissue and may help researchers to discuss important questions about development and brain disorders that occur during these early stages of life.


The organoid,described in the magazine Nature, they have similar components to the of a brain of an embryo's 9-10 weeks of age, said in a press conference, the lead author of the study, Madeline Lancaster, researcher at the Institute of biotechnology Molecular of the Austrian Academy of the sciences in Vienna. She and her colleagues have created hundreds of these organoids.


In this first stage of human development, several key regions of the brain can distinguish already, including the dorsal cortex, the ventral forebrain, choroid Plexus - generated spinal fluid- and regions that are similar to the midbrain and the rear brain. Lancaster and his colleagues claim to have identified some of these regions in these new minicerebros.


However, models made from stem cells, these regions are situated in a natural way in the same place to occupy in a normal brain. [Read more about artificial brain]


The organoid also lack certain parts that the brains of human embryos of 9 weeks have: the most important thing, the cerebellum, It is involved in the motor movement. In addition to the hippocampus, a structure in the form of seahorse crucial for memory, that rarely was detected in these structures similar to brains.

Source: [en línea] Alicante (ESP):, 17 October of 2013 [REF. 03 de septiembre de 2013] Available on Internet:






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