With the right rehabilitation, paralyzed rats learn to grip again

16 06 2014

After a large stroke, motor skills barely improve, even with rehabilitation. An experiment conducted on rats demonstrates that a course of therapy combining the stimulation of nerve fiber growth with drugs and motor training can be successful. The key, however, is the correct sequence: Paralyzed animals only make an almost complete recovery if the training is delayed until after the growth promoting drugs have been administered.


A constricted carotid artery – as pictured here above right – can lead to a stroke. (Photo: Zephyr / Science Photo Library)

A constricted carotid artery – as pictured here above right – can lead to a stroke. (Photo: Zephyr / Science Photo Library)


Only if the timing, dosage and kind of rehabilitation are right can motor functions make an almost full recovery after a large stroke. Rats that were paralyzed down one side by a stroke almost managed to regain their motor functions fully if they were given the ideal combination of rehabilitative training and substances that boosted the growth of nerve fibers. Anatomical studies confirmed the importance of the right rehabilitation schedule: Depending on the therapeutic design, different patterns of new nerve fibers that sprouted into the cervical spinal cord from the healthy part of the brain and thus aid functional recovery to varying degrees were apparent. The study conducted by an interdisciplinary team headed by Professor Martin Schwab from the Brain Research Institute at the University of Zurich and ETH Zurich’s Neuroscience Center is another milestone in research on the repair of brain and spinal cord injuries.


“This new rehabilitative approach at least triggered an astonishing recovery of the motor skills in rats, which may become important for the treatment of stroke patients in the future,” says first author Anna-Sophia Wahl. At present, patients have to deal with often severe motor-function, language and vision problems, and their quality of life is often heavily affected.


Allow nerves to grow first, then train


On the one hand, the treatment of rats after a stroke involves specific immune therapy, where so-called Nogo proteins are blocked with antibodies. These proteins in the tissue around the nerve fibers inhibit nerve-fiber growth. If they are blocked, nerve fibers begin to sprout in the injured sections of the brain and spinal cord and relay nerve impulses again. On the other hand, the stroke animals, whose front legs were paralyzed, underwent physical training – namely, gripping food pellets. All the rats received antibody treatment first to boost nerve-fiber growth and – either at the same time or only afterwards – motor training.


The results are surprising: The animals that began their training later regained a remarkable 85 percent of their original motor skills. For the rats that were trained straight after the stroke in parallel with the growth-enhancing antibodies, however, it was a different story: At 15 percent, their physical performance in the grip test remained very low.


Meticulous design very promising


The researchers consider timing a crucial factor for the success of the rehabilitation: An early application of growth stimulators – such as antibodies against the protein Nogo-A – triggers an increased sprouting and growth of nerve fibers. The subsequent training is essential to sift out and stabilize the key neural circuits for the recovery of the motor functions. For instance, an automatic, computer-based analysis of the anatomical data from the imaging revealed that new fibers in the spinal cord sprouted in another pattern depending on the course of treatment. By reversibly deactivating the new nerve fibers that grow, the neurobiologists were ultimately able to demonstrate for the first time that a group of these fibers is essential for the recovery of the motor function observed: Nerve fibers that grew into the spinal cord from the intact front half of the brain – changing sides – can reconnect the spinal cord circuits of the rats’ paralyzed limbs to the brain, enabling the animals to grip again.


“Our study reveals how important a meticulous therapeutic design is for the most successful rehabilitation possible,” sums up study head Martin Schwab. “The brain has enormous potential for the reorganization and reestablishment of its functions. With the right therapies at the right time, this can be increased in a targeted fashion.”


Imagen de previsualización de YouTube



Ethz.ch [en línea] Zürich (CH): ethz.ch, 16 de junio de 2014 [ref. 13 de junio de 2014] Disponible en Internet:


Uso de la realidad virtual en rehabilitación de lesionados medulares

29 08 2013

Un artículo sobre el uso de la realidad virtual en rehabilitación de lesionados medulares mejor publicación científica de 2012

El equipo de Biomecánica y Ayudas Técnicas del Hospital Nacional de Parapléjicos ha sido distinguido con el premio al mejor artículo científico, publicado en la revista Rehabilitación (Madr) durante el año 2012, en el que se evalúa la eficacia de la realidad virtual en la rehabilitación de pacientes con lesión medular.



El artículo científico, reconocido en el último congreso de la Sociedad Española de Rehabilitación (SERMEF) celebrado en Salamanca, se refiere concretamente a la  experiencia clínica en  la utilización del sistema llamado TOyRA, un dispositivo que consta de sensores inerciales que capturan el movimiento del paciente, los reproduce en forma de avatar en un monitor y puede medir de forma objetiva diferentes variables.


Según el responsable de  Biomecánica y Ayudas Técnicas, Ángel Gil, “la principal conclusión del estudio es que el sistema de rehabilitación TOyRA se presenta como una óptima herramienta terapéutica. Según los datos  puede ofrecer mejores resultados funcionales que la realización en solitario de los métodos tradicionales en el tratamiento de los déficits motores de los miembros superiores en lesionados medulares”.


Con el reconocimiento de Rehabilitación (Madr), TOyRA obtiene su tercer galardón por su contribución a la mejora de la calidad de vida de los lesionados medulares. Anteriormente la revista Actualidad Económica eligió TOyRa como una ‘Las 100 mejores ideas del año 2008′ y la  revista Computing, semanario especializado en Tecnologías de la Información, lo premió en la categoría “I+D+i”.


TOyRA es el resultado de un proyecto nace fruto de la colaboración de la Fundación Rafael del Pino, la empresa Indra y el Hospital Nacional de Parapléjicos, centro que gestiona el Gobierno de Castilla la Mancha.


Acceder al artículo completo.



Infomedula.org [en línea] Toledo (ESP): infomedula.org, 29 de agosto de 2013 [ref. 23 de agosto de 2013] Disponible en Internet: http://www.infomedula.org/index.php?option=com_content&view=article&id=991%3Aun-articulo-sobre-el-uso-de-la-realidad-virtual-en-rehabilitacion-de-lesionados-medulares-mejor-publicacion-cientifica-de-2012-&catid=35%3Ahospital&lang=es